Cornea Donor Study (CDS)

Cornea Donor Study (CDS)

 

The Cornea Donor Study (CDS) was originally designed as a prospective cohort study to determine whether the graft-failure rate over a 5-year follow-up period is equivalent with corneal tissue from donors older than 65 years of age compared with that from younger donors; to assess the relationship between donor: recipient ABO compatibility and graft failure due to rejection; and to assess corneal endothelial cell density as an indicator of the health of the cornea and as a surrogate outcome measure (in an optional specular microscopy ancillary study). Eligible subjects were 40 to 80 years of age, with corneal disease characterized by the presence of a condition associated with endothelial dysfunction, including pseudophakic corneal edema, Fuchs’ dystrophy, posterior polymorphous dystrophy, endothelial failure from another cause, interstitial keratitis (nonherpetic), or perforating corneal injury.  The study was extended to determine the overall 10-year survival rate for moderate risk grafts and to determine whether the graft-failure rate is equivalent with corneal tissue from donors older than 65 years of age compared with that from younger donors.

For a list of publications pertaining to this protocol please see publications list.

 

 

 

 

 

 

 

 

 


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